Mississippi Code Title 65. Highways, Bridges and Ferries § 65-41-55

(1) The following highways, roads or streets located in the State of Mississippi are hereby designated as an official Mississippi Scenic Byway to be known as the “Mississippi Delta Great River Road Scenic Byway,” pursuant to Section 65-41-1 et seq.:

Begin at the Tennessee state line and travel south on U.S. Highway 61 to the intersection of Mississippi Highway 161. Continue on Mississippi Highway 161 to the Town of Walls, Mississippi, and travel south on Old Highway 61 through DeSoto County and Tunica County to the intersection with U.S. Highway 49 near Lula, Mississippi. Continue northwest on U.S. Highway 49 to the intersection with Mississippi Highway 1, and travel south along Mississippi Highway 1. Continue south along Mississippi Highway 1 through Coahoma County, Bolivar County, Washington County, east along Mississippi Highway 1 at Sharkey County and then south along Mississippi Highway 1 at Issaquena County. Continue on Mississippi Highway 1 south to the intersection of U.S. Highway 61 at Mississippi Highway 1 at Onward; continue south along U.S. Highway 61 to the Issaquena/Warren County line. This terminates the “Mississippi Delta Great River Road Scenic Byway.”

(2) Outdoor advertising as identified in the Mississippi Delta Great River Road Scenic Byway Corridor Management Plan shall be allowed on Mississippi Highway 1 and U.S. Highway 61 within the corporate limits of the impacted municipalities along the byway subject to the zoning and signage statutes and ordinances of the state and the impacted municipalities. Outdoor advertising outside of a municipality's corporate limit must be in compliance with applicable local, state and federal guidelines.