Code of Federal Regulations Title 9. Animals and Animal Products § 9.311.12 Epithelioma of the eye

(1) The affection has involved the osseous structures of the head with extensive infection, suppuration, and necrosis;

(2) There is metastasis from the eye, or the orbital region, to any lymph node including the parotid lymph node, internal organs, muscles, skeleton, or other structures, regardless of the extent of the primary tumor;  or

(3) The affection, regardless of extent, is associated with cachexia or evidence of absorption or secondary changes.