Experiments have shown that certain cholinesterase-inhibiting pesticides when fed
together to test animals are more toxic than the sum of their individual toxicities
when fed separately. One substance potentiates the toxicity of the other. Important toxicological interactions also have been observed between pesticides
and other substances. Wherever there is reason to believe that a pesticide chemical for which a tolerance
is proposed may interact with other pesticide chemicals or other substances to which
man is exposed, it may be necessary to require special experimental data regarding
potentiation capacities to evaluate the safety of the proposed tolerance. This necessarily will be determined on a case-by-case basis.
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